| Main Title |
Support: Letter from Dupont to USEPA with Summary of Final Results of a 90-Day Oral Gavage Study of Alcohols, C8-14, Gamma-Omega-Perfluoro in Rats, dated 08/31/2001. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2001 |
| Report Number |
8EHQ-0901-14880 |
| Stock Number |
OTS0560015-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Alcohols C8-14 gamma-omega-perfluoro ;
Subchronic toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
CAS No 68391-08-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0560015-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
The test material was administered by gavage to 4 groups of male and female rats at dosages of 0, 25, 100, or 250 mg/kg/day for approximately 90 days. In the subchronic study, body weights, food consumption, and clinical signs were evaluated weekly. Clinical pathology endpoints were evaluated on weeks 7 and 13 of the study, and following a 36- and 92-day recovery period. The rate of hepatic oxidation, a measure of peroxisome proliferation, was determined in rats following approximately 10 or 90 days oftreatment and after a 36- and 92-day recovery period. Neurobehavioral and ophthalmology assessments were also performed prior to dosing, during week 13, and near the end of the 36-day recovery period. After approximately 90 days of dosing, 10 rats/sex/dose level were sacrificed and given a gross and microscopic pathology examination. After 36 days of recovery, 10 rats/sex from the control and high dose group were evaluated and an additional 5/sex/dose were evaluated at the 92-day recovery period. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
4 Sep 2001 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010502080 |
| Origin |
NTIS |
| Type |
CAT |
