| Main Title |
Support: Letter from Dupont to USEPA with Summary and Results of a Two-Week Inhalation Toxcity Study with 1,N-Diiodoperfluoroalkanes in Rats, dated 05/07/2002. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2002 |
| Report Number |
8EHQ-0502-13829 |
| Stock Number |
OTS0559066-3 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
1-N-diiodoperfluoroalkanes ;
Subchronic toxicity ;
Mammals ;
Rats ;
Inhalation ;
Pharmaco kinetics ;
CAS No 375-50-8 ;
CAS No 375-80-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0559066-3 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
Groups of male rats were exposed 6 hours daily for 2 weeks (9 exposures) via inhalation to 0, 0.1, 2.5, or 25 ppm of the test material. The exposure period was followed by a 2-week recovery period. Rats were weighed and observed for clinical signs on a daily basis. Food consumption was determined on a weekly basis. Clinical pathology and anatomic pathology evaluations were conducted on rats at the end of the exposure and recovery periods. One day following the final exposure, serum levels of thyroid stimulating hormone (TSH), triiodothyronine (Ts), and thyroxine (Ta) were measured in all rats. Rats exposed at 2.5 or 25 ppm had significantly lower mean body weights during the exposure and recovery phases and significantly lower mean body weight gains, food consumption, and food efficiency during the exposure period. No clinical signs of toxicity attributable to exposure to the test material were observed. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
9 May 2002 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010501660 |
| Origin |
NTIS |
| Type |
CAT |
