| Main Title |
Support: Letter from Dow Corning Corp. to USEPA re: Repeat Insult Patch Test of DC 3-8015 Int (Platinum 2) and DC 2-0707 Int (Platinum 4) in Human Subjects, dated 09/28/1998. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Report Number |
8EHQ-1098-13847 |
| Stock Number |
OTS0559083-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Platinum 2 ;
Platinum 4 ;
Primary dermal sensitization ;
Mammals ;
Guinea pigs ;
Dermal ;
CAS No 2627-95-4 ;
CAS No 68083-19-2 ;
CAS No 68478-92-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0559083-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Repeated human insult patch studies were conducted on both platinum intermedi- ates to assess their potential to cause skin sensitization by long repeated topical applications of test substance to the skin of selected subjects. The repeated insult patch test is a predictive patch study that can detect weak human sensitizers which require multiple applications to induce a cell-mediated (Type IV) immune response sufficient to cause an allergic reaction. Each study was comprised of three phases: (1) induction, (2) rest, and (3) challenge. The induction phase consisted of nine consecutive applications of the test substance and subsequent evaluation of patch sites. Semi-ocolusive 2cm x 2cm patches were applied to the infrascapular area of the back to the left or right of the midline. Following the ninth evaluation, the subjects were dismissed for a 14-day rest period. The challenge phase was initiated during the sixth week of the study, with identical patches applied to sites previously unexposed to the study material. These patches were removed after 24 hours and the sites graded after an additional 24 and 48 hours, i.e., 48 and 72 hours after application. One hundred four subjects completed the study. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
5 Oct 1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010501740 |
| Origin |
NTIS |
| Type |
CAT |
