||Toxicological Investigationof Maleic Anhydride, Lot No. QB1151 with Cover Letter.
||Monsanto Co., St. Louis, MO.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Laboratory animals ;
Lethal doses ;
Signs and symptoms ;
Dose levels ;
Maleic anhydride ;
CAS No 108-31-6
||Some EPA libraries have a fiche copy filed under the call number shown.
||In an acute toxicity study, male and female Sprague-Dawley rats (2 males and 3 females/group, except highest-dose level group which had 4 males and 1 female) were given single gavage exposures to maleic anhydride (as a 10% solution/suspension in corn oil). Dose levels of 316, 398, 501, and 631 mg/kg resulted in the deaths of 0, 1, 3, and 4 animals, respectively (duration of observation period was not reported although the survival time was reported to be one to four days). The LD50 is 495 (410 to 580) mg/kg. Toxic symptoms observed included loss of appetite, diarrhea, and increasing weakness. Gross pathology observed at autopsy included renal and liver congestion, and inflammation of the gastric mucosa.
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|PUB Date Free Form
||5 Nov 1984
||PC A99/MF A99