||Summary of the Toxicity of Maleic Anhydride with Cover Letter.
||Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Skin irritation ;
Laboratory animals ;
Guinea pigs ;
Maleic anhydride ;
Union Carbide Corporation ;
CAS No 108-31-6
||Some EPA libraries have a fiche copy filed under the call number shown.
||Maleic anhydride is recognized as a very active skin irritant. Single doses were administered by mouth and by skin absorption to determine if its internal toxicity is correspondingly high. The sample was received 1-3-40 from South Charleston on plant order S-38902. It was of the usual commercial grade. The LD(sub 50) for rats by mouth was found to be 1.1 gm./kg., and for guinea pigs 0.7 gm./kg. Even 5 gm./kg. in the form of a 10% solution did not kill guinea pigs when kept four days on the skin. Death was rapid. Bile was orange or red, kidney was pale, liver was congested, stomach was congested and injected for doses by mouth. Death was apparently due largely to shock and digestive tract irritation, accompanied by injury to liver and kidney. The 10% aqueous solution left on guinea pig skin for four days produced slight local necrosis and a papular eruption, without any internal changes. Apparently little penetrated the skin. Some applications of melted anhydrous maleic anhydride were made. All animals died, even at a dosage of 1 gm./kg. Death was apparently due to shock and infection following the very severe local necrosis produced. In dilute solutions by mouth maleic anhydride is moderately but not extremely toxic. On the skin a 10% solution is slightly necrotic, but does not penetrate appreciably into the body.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC.
||Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at email@example.com. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
|PUB Date Free Form
||11 Dec 1984
||PC A04/MF A04