| Main Title |
Effect of Phenobarbitol on the Gamma-Glutamyltranspeptidase Activity and the Remodeling of Nodules Induced by the Initiation-Selection Model. |
| Author |
Herren-Freund, S. L. ;
Pereira, M. A. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/162; |
| Stock Number |
PB86-107216 |
| Additional Subjects |
Environmental surveys ;
Phenobarbital ;
Enzymes ;
Toxicology ;
Laboratory animals ;
Dosage ;
Exposure ;
Rats ;
Mathematical models ;
Liver diseases ;
Reprints ;
Nitrosamine/diethyl ;
Transpeptidase/glutamyl ;
Cancer
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-107216 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Enzyme-altered foci and nodules have been observed in the liver of rats treated with diethylnitrosamine(DENA) followed by selection with 0.02% 2-acetylaminofluorene (2-AAF) and a partial hepatectomy (PH) (DENA-2AAF-PH treatment). The authors determined the effect of subsequent administration of phenobarbital or of a second dose of DENA on the progression or reversion of these lesions. After the removal of 2-AAF from the diet, one group of rats received no further treatment, another group received subsequent exposure to phenobarbital, a third group received a second dose of DENA, and a fourth group received a second dose of DENA without the partial hepatectomy during the 2-AAF exposure. The rats were sacrificed at various times up to 58 weeks following the 2-AAF exposure. Subsequent exposure to phenobarbital did not alter the tumor incidence in the DENA-2AAF-PH treated rats while the second dose of DENA resulted in an increased incidence of hyperplastic nodules and hepatocellular carcinomas as well as an increase in renal tubular adenomas and carcinomas. |
| Availability Notes |
Pub. in Cancer Letters 27, p153-161 Jun 85. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effect of Phenobarbitol on the Gamma-Glutamyltranspeptidase Activity and the Remodeling of Nodules Induced by the Initiation-Selection Model. |
| PUB Date Free Form |
c1985 |
| Category Codes |
6T; 6A; 7D; 57Y; 68G; 57B; 99A |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
535326985 |
| Origin |
NTIS |
| Type |
CAT |
