| Main Title |
1,2-Dibromoethane Causes Rat Hepatic DNA Damage at Low Doses. |
| Author |
Kitchin, K. T. ;
Brown, J. L. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/349; |
| Stock Number |
PB87-184685 |
| Additional Subjects |
Dosage ;
Toxicity ;
Liver diseases ;
Solvents ;
Genetics ;
Rats ;
Carcinogens ;
Alpha amino carboxylic acids ;
Glutathione ;
Cytochromes ;
Reprints ;
Dibromoethane ;
Halogenated hydrocarbons ;
Mutagens ;
SGPT(Serum Alanine Transaminase)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-184685 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Two oral administrations of 1,2-dibromoethane to adult female rats at doses above 10 micromoles/kg (1.9 mg/kg) caused DNA damage as determined by the alkaline elution technique. Far greater doses (300 micromoles/kg, 56.4 mg/kg) of 1,2-dibromoethane were required to cause other hepatic biochemical effects, such as increased activity of ornithine decarboxylase. In the dose range of 10-300 micromoles/kg, no increase in the activity of serum enzyme alanine transaminase (SGPT) was observed. Of the six organs studied, liver showed the largest amount of DNA damage. Thus, the carcinogen 1,2-dibromoethane caused substantial DNA damage at doses far below those required to show other biochemical effects or frank liver toxicity. |
| Supplementary Notes |
Pub. in Biochemical and Biophysical Research Communications, v141 n2 p723-727A, 15 Dec 86. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: 1,2-Dibromoethane Causes Rat Hepatic DNA Damage at Low Doses. |
| PUB Date Free Form |
1986 |
| Category Codes |
68G; 57F; 57O; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
718323445 |
| Origin |
NTIS |
| Type |
CAT |
