| Main Title |
Subchronic (3-month) Oral Toxicity Study in the Rat with Lx1106-01 via Gavage (Final Report) with Attachments and Cover Letter Dated 04/24/1991 (Sanitized). |
| CORP Author |
Bio-Dynamics Research and Development Corp., Eugene, OR.; Mobil Oil Corp., New York.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1991 |
| Report Number |
86-910000807S |
| Stock Number |
OTS0529439 |
| Additional Subjects |
Toxicology ;
Health effects ;
Solvent Naphtha (petroleum) Light Aromatic (64742-95-6) ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 64742-95-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0529439 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
411p |
| Abstract |
Solvent Naphtha, light aromatic (C8-10) (CAS No. 64742-95-6) was evaluated for subchronic toxicity. The test substance was administered to rats (10/sex/group) by oral gavage at dose levels of 0, 500, 750, and 1,250 mg/kg/day, 7 days/week for 3 months. No treatment-related deaths were observed. Treated animals had excessive salivation and anogenital staining. There was a statistically significant decrease in body weight in males in all the treated groups, and significant increases in serum glutamic pyruvic transaminase in both sexes and of alkaline phosphatase in males in the high dose group as compared to controls. There were no effects on the eyes, food consumption, or hematology. A dose-related increase in liver, kidney, liver/body, and kidney/body weights was noted. The lowest dose in this study is a LOAEL for changed organ weights and decreased body weight. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Mobil Oil Corp., New York. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1991 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A19/MF A19 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803080 |
| Origin |
NTIS |
| Type |
CAT |
