| Main Title |
Supplemental Information: Induction of Leydig Cell Adenomas by Ammonium Perfluorooctanoate: A Possible Endocrine-Related Mechanism. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
29 Oct 1991 |
| Year Published |
1991 |
| Report Number |
8HEQ-1091-0394; |
| Stock Number |
OTS-0204926-3 |
| Additional Subjects |
Toxicity ;
Cells(Biology) ;
Adenoma ;
Gavage ;
Rats ;
Genotoxicity ;
Dosage ;
Endocrine glands ;
Testosterone ;
Exposure(Physiology) ;
Laboratory animals ;
Hormones ;
Laboratory tests ;
Ammonium perfluorooctanoate ;
Leydig cells ;
EI Du Pont de Nemours and Company
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0204926-3 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
42p |
| Abstract |
Induction of Leydig Cell Adenomas by Ammonium Perfluorooctanoate: A Possible Endocrine-Related Mechanism. Cook, J.C., Murray, S.M., Frame, S.R., and Hurtt, M.E. (1991). Toxicol. Appl. Pharmacol. 000, 000-000. Ammonium perfluorooctanoate (C8) produced an increased incidence of Leydig cell adenomas in Crl:CD(trademark)BR (CD) rats fed 300 ppm for two years. A hormonal (non-genotoxic) mechanism was examined since C8 was negative in short-term tests for genotoxicity. Adult made CD rats were gavaged with either 0, 1, 10, 25, or 50 mg/kg C8 for 14 days. In addition, a control group was pair-fed to the 50 mg/kg C8 group. A dose-dependent decrease in body and relative accessory sex organ (ASO) weights was seen, with the relative ASO weights of the 50 mg/kg group significantly less than the pair-fed control. Serum estradiol levels were elevated in the 10, 25, and 50 mg/kg C8-treated animals. Estradiol levels were 2.7-fold greater in the 50 mg/kg C8 group when compared to the pair-fed control. The increase in serum estradiol levels occurred at the same dose levels as the increase in hepatic Beta-oxidation activity. A statistically significant downward trend with dose was seen in serum testosterone levels when compared with the ad libitum control. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y; 57F; 57B |
| NTIS Prices |
PC A04/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
009400400 |
| Origin |
NTIS |
| Type |
CAT |
