Full Record Display for the EPA National Library Catalog


Main Title Biochemical Effects of Three Chlorinated Phenols in Rat Liver.
Author Kitchin, K. T. ; Brown., J. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/522;
Stock Number PB90-232265
Additional Subjects Biochemistry ; Toxicology ; Liver ; Phenols ; Chlorinated hydrocarbons ; Leukocytes ; Rats ; Carcinogens ; Lethal dosage ; Tables(Data) ; Reprints ; Dose-response relationships ; DNA damage ; Cytochrome P-450 ; Ornithine decarboxylase ; Glutathione ; Alanine aminotransferase ; Enzyme induction
Library Call Number Additional Info Location Last
NTIS  PB90-232265 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Abstract The hepatic biochemical effects of four chlorinated oxygen containing environmental contaminants were determined. Two oral doses of 1/5 the LD50 of 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenol, 2,4,6-trichlorophenol and 2,3,4,6-tetrachlorophenol were given 21 and 4 hours before sacrifice to adult female rats. Although 2,4,6-trichlorophenol is a carcinogen in lifetime rodent studies, no evidence was found for DNA damage in rat liver or the white cells of rat blood. Similiarly no compound related changes were found in serum alanine aminotransferase, hepatic glutathione or cytochrome P-450 content. A dose of 193 mg/kg/day (slightly over the published rat LD50) of 2,3,4,6-tetrachlorophenol increased 5-fold the activity of hepatic ornithine decarboxylase. As 2,4,6-trichlorophenol did not damage DNA or induce hepatic ornithine decarboxylase (a marker of carcinogenic promotion) in the study, no explanation is apparent why this molecule is a carcinogen in rodent lifetime exposures and structurally related congeners are not. (Copyright (c) 1988 Gordon and Breach, Science Publishers, Inc.)
Supplementary Notes Pub. in Toxicological and Environmental Chemistry, v16 p165-172 Feb 88.
NTIS Title Notes Journal article.
Title Annotations Reprint: Biochemical Effects of Three Chlorinated Phenols in Rat Liver.
Category Codes 57Y; 57B
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 022221230
Origin NTIS
Type CAT