| Main Title |
U-Shaped Dose-Response Curves: Their Occurrence and Implications for Risk Assessment. |
| Author |
Davis, J. M. ;
Svendsgaard., D. J. ;
|
| CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/171; |
| Stock Number |
PB91-115808 |
| Additional Subjects |
Epidemiology ;
Toxicology ;
Lead(Metal) ;
Nervous system disorders ;
Children ;
Blood ;
Reprints ;
Dose response relationships ;
Risk assessment
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-115808 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
A class of curvilinear dose-response relationships in toxicological and epidemiological studies may be roughly described by 'U-shaped' curves. Such curves reflect an apparent reversal or inversion in the effect of an otherwise toxic agent at a low or intermediate region of the dose continuum. Several examples of U-shaped dose response functions are presented to illustrate the variety of agents and end points that can follow this form. Such findings are not thought to represent a unitary phenomenon, but may be explained through numerous possible principles or mechanisms, some of which are illustrated and discussed in general terms. U-shaped dose-response curves raise important issues for toxicological and environmental health risk assessments, particularly in the identification of no-observed-effect levels and in the evaluation of multiple outcomes and trade-offs between potential risks and benefits of a given agent. It is especially important to avoid focusing exclusively on an apparent improvement in one end point and failing to consider other, possibly deleterious effects of the same agent. |
| Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v30 p71-83 1990. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: U-Shaped Dose-Response Curves: Their Occurrence and Implications for Risk Assessment. |
| Category Codes |
68G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/23 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
036522842 |
| Origin |
NTIS |
| Type |
CAT |
