| Main Title |
Effect of lead on gamma amino butyric acid synthesis / |
| Author |
Moses, Henry Archie.
|
| CORP Author |
Meharry Medical Coll., Nashville, Tenn. Dept. of Biochemistry and Nutrition.;Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div. |
| Publisher |
U.S. Environmental Protection Agency, Health Effects Research Laboratory, |
| Year Published |
1978 |
| Report Number |
EPA/600/1-78/009; EPA-R-802370 |
| Stock Number |
PB-277 022 |
| OCLC Number |
42838641 |
| Subjects |
Brain chemistry--Research ;
Lead--Toxicology
|
| Additional Subjects |
Lead(Metal) ;
Enzyme inhibitors ;
Toxicology ;
Biosynthesis ;
Brain ;
Rats ;
Experimental data ;
Ingestion(Biology) ;
Bioassay ;
Dosage ;
Toxicity ;
Lead poisoning ;
Toxic diseases ;
Tissues(Biology) ;
Absorption(Biology) ;
Experimental data ;
Butyric acid/4-amino ;
Neurochemistry ;
Decarboxylase/glutamic acid
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-78-009 |
c.1 |
Headquarters Library/Washington,DC |
06/09/2014 |
| EKBD |
EPA-600/1-78-009 |
|
Research Triangle Park Library/RTP, NC |
02/23/2000 |
| ELBD ARCHIVE |
EPA 600-1-78-009 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| NTIS |
PB-277 022 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
ix, 28 p. ; 28 cm. |
| Abstract |
The project studies the inhibitory effect of lead on the enzymatic activity of brain glutamic amino acid decarboxylase (GADC). The enzyme is responsible for the catalytic formation of gamma amino butyric acid (GABA) inhibitory neurons which is believed to be involved with the transmission of inhibitory impulses in the brain. Lead nitrate solution was available to Sprague-Dawley female rats ad libitum and the quantity of lead ingested was determined by the volumes consumed. During the course of these experiments, animals were examined for weight loss, activity, and excitability and other behavioral manifestations of lead toxicity. At autopsy, the tissues selected for lead determinations were brain, liver, bone (femur). In another series of experiments GADC was isolated from fresh bovine brain tissue, and in vitro studies were performed to determine the nature of lead inhibition of the enzyme. Subsequently, Se and Cd inhibition of the enzyme were studied and compared to lead inhibition. The activity of the enzyme GADC in brain tissue homogenates of rats drinking lead nitrate solutions was less than the activity determined in control rats. When the inhibiting effect of Pb, Cd, and Se on GADC activity were compared, Pb proved to be the most potent inhibitor, while Cd showed less inhibition, showed no inhibition of enzyme activity. |
| Notes |
"EPA-600/1-78-009". EPA grant no. R-802370; EPA project officer: Larry L. Hall. Bibliography: p. 14. |
| Place Published |
Research Triangle Park, NC |
| Access Notes |
Also available via the World Wide Web. |
| Corporate Au Added Ent |
Health Effects Research Laboratory (Research Triangle Park, N.C.); United States. Environmental Protection Agency. Office of Research and Development.; Meharry Medical College. School of Medicine. |
| Title Ser Add Ent |
Research reporting series. Environmental health effects research ; EPA 600/1-78/009. |
| PUB Date Free Form |
January 1978 |
| Series Title Untraced |
Environmental health effects research series ; EPA 600/1-78/009 |
| Category Codes |
6T; 6A; 57Y; 57B |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| Control Number |
323733082 |
| OCLC Time Stamp |
20140606141030 |
| Language |
eng |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01439cam 2200337Ka 45020 |
