Main Title |
Molecular Connectivity Study of Phenols and Their Toxicity to Fish. |
Author |
Hall, L. H. ;
Kier, L. B. ;
|
CORP Author |
Eastern Nazarene Coll., Quincy, MA. Dept. of Chemistry. ;Virginia Commonwealth Univ., Richmond.;Environmental Research Lab.-Duluth, MN. |
Year Published |
1984 |
Report Number |
EPA/600/J-84/391; |
Stock Number |
PB87-167722 |
Additional Subjects |
Phenols ;
Toxicity ;
Fishes ;
Minnows ;
Chemical analysis ;
Chemical tests ;
Lake Superior ;
Reprints ;
Water pollution effects(Animals) ;
Molecular connectivity ;
Pimephales promelas
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-167722 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
A set of 25 substituted phenols have been examined in a QSAR study of their toxicity to fathead minnows, Pimephales promelas. The acute toxicities were measured in a flow-through system over a 96 hr. period as lethal concentration to kill 50 percent of the population, LC50. The negative logarithm of the toxicity, pLC50, which ranged over three orders of magnitude from 3.21 to 6.20, is correlated with molecular connectivity indexes. The best correlation was found with the simple index (1) chi and the valence index (3) chi rho with r=0.934 and s=0.296. The study includes an analysis of the stability of the regression model with respect to selection of the data set as well as the reliability of the model as compared to chance correlations. The structural interpretation of the regression model is also discussed. (Copyright (c) Bull. Environ. Contam. Toxicol. January 1984.) |
Supplementary Notes |
Pub. in Bulletin of Environmental Contamination and Toxicology 32, p53-59 Jan 84. Prepared in cooperation with Virginia Commonwealth Univ., Richmond. Sponsored by Environmental Research Lab.-Duluth, MN. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Molecular Connectivity Study of Phenols and Their Toxicity to Fish. |
PUB Date Free Form |
c1984 |
Category Codes |
57Y; 68D |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
715626828 |
Origin |
NTIS |
Type |
CAT |