| Main Title |
1,3-dichloro-2-propanol: 13-week Gavage Toxicity Study in Sprague-dawley Rats (Final Report) with Cover Letter. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1989 |
| Report Number |
40-8915319 |
| Stock Number |
OTS0526377 |
| Additional Subjects |
Toxicology ;
Health effects ;
1 ;
3-dichloro-2-propanol ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 96-23-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0526377 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
79p |
| Abstract |
1,3-Dichloro-2-propanol (DCP) was evaluated for subchronic toxicity in Sprague-Dawley rats (10/sex/dose group) administered dose levels of 0, 0.1, 1, 10, or 100 mg DCP/kg bw/day by gavage in distilled water 5 days/week for 13 weeks. No adverse clinical signs were observed during the study in any dose group. Final body weight gain was 8% lower in high-dose males than in control rats. Sporadic decreases in food consumption were observed in high-dose males and females. Exposure to 100 mg/kg DCP induced a statistically significant decrease in hemoglobin and hematocrit in both sexes. High-dose females showed a significant increasein urinary proteins, but this effect was not observed in males. Numerous clinical chemistry effects detected were a reflection of liver damage in high-dose males and females and of kidney damage in high-dose females. Absolute and relative liver and kidney weights were significantly increased in high-dose groups. Gross pathology effects attributed to DCP-treatment were limited to gastric irritation in the 10 and 100 mg/kg groups. Histopathological alterations due to treatment with DCP were confined to the stomach, liver, and kidney of rats given 10 and 100 mg/kg, and to the nasal tissues of rats in the high-dose groups. The 1 mg/kg dose was the no-adverse-effect level. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1989 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802700 |
| Origin |
NTIS |
| Type |
CAT |
