| Main Title |
90-day Oral (dietary Administration) Toxicity Studies of 2-eha in the Mouse & Rat & Developmental Toxicity Evaluations of 2-eha Administred in Rats & White Rabbits W-cover Letter. |
| CORP Author |
Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8897194 |
| Stock Number |
OTS0525548 |
| Additional Subjects |
Toxicology ;
Health effects ;
2-ethylhexanoic Acid ;
Subchronic Toxicity ;
Mammals ;
Mice ;
Oral ;
Rats ;
Reproduction/fertility Effects ;
Teratogenicity ;
Gavage ;
Rabbits ;
Toxic substances ;
Laboratory animals ;
CAS No 149-57-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0525548 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1072p |
| Abstract |
2-Ethylhexanoic acid (EHA) was evaluated for subchronic toxicity to B6C3F1 mice (10/sex/group) administered dietary concentrations of 0, 0.1, 0.5, or 1.5% EHA for 90 days. No effect was noted on survival. Reduced body weight and food consumption was seen in the 1.5% groups. Increased liver weight was noted in the mid- and high-dose group, along with altered blood chemistry. The 90-day NOAEL was 0.1% EHA. Identical tests with rats led to similar effects, but only at the high-dose level. The 90-day NOAEL for rats was 0.5% EHA. In a developmental study, Fischer 344 rats (25 plug-positive females/group) were orally exposed by gavage to 0, 100, 250, or 500 mg/kg/day EHA in corn oil on gestation days 6 through 15. Maternal toxicity was noted in high-dose dams (ocular discharge, periocular encrustation, increased absolute and relative liver weights). In the high-dose group, fetal body weights/litter were decreased and fetal skeletal variations were increased. Exposure of New Zealand white rabbits (15 mated females/group) to oral doses of 0, 25, 125, or 250 mg/kg/day of EHA by gavage in corn oil on gestation days 6 through 18 led to maternal toxicity (1 mortality; 1 doe aborted) at 125 mg/kg/day and above. No embryotoxicity, fetotoxicity or teratogenicity was observed at any dose. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A99/MF A99 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802670 |
| Origin |
NTIS |
| Type |
CAT |
