| Main Title |
Support: Final Report, a Dermal Irritation/corrosivity Study in Rabbits with Di-amylamine, with Cover Letter dated 4/13/1998. |
| CORP Author |
Springborn Labs., Inc., Wareham, MA.; Elf Atochem North America, Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Report Number |
89980000087 |
| Stock Number |
OTS0559239 |
| Additional Subjects |
Toxicology ;
Health effects ;
Diamylamine ;
Primary Dermal Irritation ;
Mammals ;
Rabbits ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 2050-92-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0559239 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
55p |
| Abstract |
Dermal irritancy and corrosivity of di-amylamine (CAS No. 2050-92-2) was evaluated in 6 New Zealand White rabbits each administered three 0.5 mL dermal applications upon intact skin at 3 distinct sites. The semi-occlusive bindings covering the 3 applications were removed and the skin cleansed of any residual test article at 3-minute, 1-hour, and 2-hour intervals, respectively. Signs of irritation or corrosion were assessed immediately and at 1 hour following removal of the patches according to the Dermal Grading System for Potential In-Depth Injury at the 3-minute sites and by the method of Draize at the 1- and 2-hour sites. Upon a 1-hour assessment after removal of the 2-hour application, humane euthanasia of all treated animals due to excessive dermal irritation terminated study. Nearly all test sites for all exposure periods exhibited slight to moderate blanching initially. The 3-minute exposure also produced slight necrosis at 1 site that was more severe and prevalent with increasing periods of exposure. Both 1-hour and 2-hour applications were also characterized by severe erythema and slight-moderate edema. One hour following removal of patches, grade 1-4 necrosis was noted on all sites of 3-minute or 1-hour exposures, while grade 1-3 eschar and severe edema was found on all 2- hour exposure sites. Superficial lightening and erythema extending beyond the test site were also noted in both 1- and 2-hour sites, while ulceration beyond the test site characterized 2-hour sites only 1 hour after patch removal. Researchers concluded that di-amylamine is corrosive to rabbit skin at 3- minute, 1-hour and 2-hour long exposures. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Elf Atochem North America, Philadelphia, PA. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803970 |
| Origin |
NTIS |
| Type |
CAT |
