| Main Title |
79-week Progress Report: an 18-month Vapor Inhalation Safety Evaluation Study in Hamsters with Attachments and Cover Sheet Dated 07/17/1989 (Sanitized). |
| CORP Author |
Hazleton Labs., Falls Church, VA.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
86-890001401S |
| Stock Number |
OTS0521018 |
| Additional Subjects |
Toxicology ;
Health effects ;
Methyl Methacrylate (80-62-6) ;
Chronic Toxicity ;
Mammals ;
Hamsters ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 80-62-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0521018 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
24p |
| Abstract |
Chronic toxicity was evaluated in hamsters (53-59/sex/dose group) exposed to methyl methacrylate vapor at concentrations of 0, 25, 100, or 400 ppm for 6 hours/day, 5 days/week for 18 months. Mortality rates, in the control, low-, mid-, and high-dose groups were 34.5, 43.4, 35.7, and 60.0% (males) and 72.7, 64.9, 62.5 and 68.8% (females), respectively. Treatment did not affect body weight gain, hematocrit level, or erythrocyte and leukocyte counts. Hemoglobin concentration was decreased in high-dose males sampled at 79 weeks, but was normal in all other groups. Numerous gross abnormalities were seen in control and treated rats, but no statistical analysis of these results was reported. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Rohm and Haas Co., Philadelphia, PA. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802410 |
| Origin |
NTIS |
| Type |
CAT |
