| Main Title |
Subchronic Inhalation Toxicity Study with Formamide in Rats with Attachments and Cover Letter Dated 04/27/1988 (Sanitized). |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1988 |
| Report Number |
86-880000232S |
| Stock Number |
OTS0514122 |
| Additional Subjects |
Toxicology ;
Health effects ;
Formamide (75-12-7) ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 75-12-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0514122 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
147p |
| Abstract |
Subchronic inhalation toxicity was evaluated in groups of 10 male Crl:CD BR rats exposed to formamide vapors at analytical concentrations of 0, 113, 500 and 1504 ppm for 6 hours/day, 5 days/week for 2 weeks. Mortality was observed in 2 rats in the 1504 ppm exposure group. Clinical observations included diarrhea, red nasal and ocular discharges, and hunched posture. Statistically significant (p < 0.05) decreases in body weights were observed in all animals in the highest exposure group. Hematological examination revealed statistically significantly (p < 0.05): decreased MCV values, platelet counts and lymphocytes in animals in the highest exposure group; increased MCHC values and decreased platelet counts in animals exposed to 500 ppm; and increased atypical lymphocytes in animals in the lowest exposure group. Clinical biochemistry findings included a statistically significant (p < 0.05) decreases in: thrombocytopenia in males at 500 and 1504 ppm; lymphopenia in animals exposed to 1504 ppm; and increases in serum cholesterol in animals exposed to 1504 ppm. There were no exposure-related urinalysis findings. Microscopic histopathological examination revealed nephrosis characterized by degeneration and necrosis of the tubular epithelium, minimal to severe renal lesions, and mineralized necrotic debris surrounded by granulomatous inflammation in male rats exposed to 1504 ppm; all other findings were condidered to be unrelated to the test material. Increased relative kidney weights were observed in animals exposed to 1504 ppm. Gross necropsy findings were not reported. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1988 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A08/MF A08 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801910 |
| Origin |
NTIS |
| Type |
CAT |
