| Main Title |
Study of Subchronic Dermal Toxicity of Formamide in the Rat; 90 Day Study (project No. 38ho295/8255) with Cover Letter dated 07/09/1984. |
| CORP Author |
Wyandotte Chemicals Corp., MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8457062 |
| Stock Number |
OTS0507213 |
| Additional Subjects |
Toxicology ;
Health effects ;
Formamide ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 75-12-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0507213 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
48p |
| Abstract |
In a subchronic toxicity study, male and female Wistar rats (10/sex/group) were dermally exposed to formamide at dose levels of 0, 300, 1000 or 3000 mg/kg/day over a period of 90 days. There were statistically significant differences between treated and control animals in the following: decreased food consumption (both sexes at high-dose level), decreased body weight gain (both sexes at high-dose level), appearance of an erythema of the skin followed by further symptoms including poor general condition, apathy, dyspnoea and staggering (both sexes at high-dose level, 55-58 days after beginning of the application), and marked signs of erythcythemia in the form of increased hemoglobin and erythrocyte counts (all treated males and high-dose females). There were other differences (statistical significance not reported) between treated and control animals in the following: increased hematocrit values and decreases in leucocyte and lymphocyte counts (mid- and high-dose males), increased mean cell volume (both sexes, mid- and high-dose groups), increased mean corpuscular concentration and creatinine values (both sexes, high-dose groups), and decreased platelets, total protein, albumin and glucose (high-dose males). No animal exhibited a value of 10% carboxyhemoglobin (limit of detection). One high-dose female, with prominent bleeding from stomach ulceration, was moribund at day 83 of the study. No histopathology results were reported. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801160 |
| Origin |
NTIS |
| Type |
CAT |
