| Main Title |
Probe Study to Determine the Maximum Tolerated Dose of PDMs Fluid in Rabbits, with Cover Letter dated 04/20/1994. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
OTS-86940001368 |
| Stock Number |
OTS0558149 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Octamethylcyclotetrasiloxane ;
Laboratory animals ;
Subchronic toxicity ;
Mammals ;
Rabbits ;
Oral ;
Diet ;
CAS No 541-02-6 ;
CAS No 541-05-9 ;
CAS No 556-67-2 ;
CAS No 63148-62-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558149 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
PDMS fluids are used in various dermal applications and Oral ingestions, a previous oral study in rabbits demonstrated signs of weight loss reduction in food consumption and death at the 225 and 1,000 mg/kg dose levels of D4 and 2,000 ag/kg of DOW CORNING 200 Fluid, 350 as. These adverse effects indicated a need for the donages to be lowered to a point where the material would not cause any signs of toxicity to the pregnant female. The present study was designed to evaluate the maximum tolerated dose of these materials. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
28 Apr 1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500840 |
| Origin |
NTIS |
| Type |
CAT |
