| Main Title |
Primary Eye Mucosa Irritation Study of Kf-996s (Dodecamethylcyclohexasiloxane) in Rabbits with Cover Letter dated 04/08/94. |
| CORP Author |
; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
86940001753 |
| Stock Number |
OTS0572800 |
| Additional Subjects |
Toxicology ;
Health effects ;
Dodecamethylcyclohexasiloxane ;
Primary Eye Irritation ;
Mammals ;
Rabbits ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 540-97-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0572800 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
33p |
| Abstract |
Primary eye mucosa irritation study of KF-996S was conducted in nine Japanese white rabbits. In conclusion, extremely slight hyperemia (score: 0.5 points) in conjunctivae was observed in the instilled side in three animals at one hour after instillation. The total score of the findings was 0.2 points. Because the hyperemia in conjunctivae was not observed on or after 24 hours post instillation, it was thought that the finding was evanescent change. In addition, such slight hyperemia in conjunctivae could appear as a result of the instillation or examination processes. Therefore, the results do not always mean that KF-996S causes irritation. The other findings, namely chemosis and discharge in conjunctivae or changes in cornea and iris were not observed at any time of observation. Additionally, any differences in findings between the washed group and the unwashed group were not observed. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028804310 |
| Origin |
NTIS |
| Type |
CAT |
