| Main Title |
2 Phenoxyethanol: Two-week Dermal Probe Study in Female New Zealand White Rabbits to Assess Hematological Effects with Cover Letter. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1985 |
| Report Number |
878216053 |
| Stock Number |
OTS0206805 |
| Additional Subjects |
Toxicology ;
Health effects ;
2-phenoxyethanol (122-99-6) ;
Subchronic Toxicity ;
Mammals ;
Rabbits ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 122-99-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0206805 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
22p |
| Abstract |
Subchronic toxicity was evaluated in groups of 10 female New Zealand White rabbits exposed to 2-phenoxyethanol for 14 consecutive days at a level of 0 or 0.91 ml/kg/day as an occluded dose to clipped, intact skin. Mortality was observed in 7 rabbits by day 8 of the experiment. Clinical observations included discoloration of the skin at the test site. Necropsy revealed hemoglobinuria; pale livers; dark kidneys and spleens; decreased hemoglobin, PCV and RBC values; increased erythrocyte indices, nucleated RBC's, leukocytes and erythrocytes; and regenerative hemolytic anemia due to intravascular hemolysis of RBC's. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1985 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801100 |
| Origin |
NTIS |
| Type |
CAT |
