| Main Title |
Heat Shock Proteins in Neural Cells [electronic resource] / |
| Type |
EBOOK |
| Author |
Richter-Landsberg, Christiane.
|
| Publisher |
Springer New York, |
| Year Published |
2009 |
| Call Number |
RC321-580 |
| ISBN |
9780387399546 |
| Subjects |
Medicine ;
Medical laboratories ;
Neurosciences ;
Cytology ;
Neurobiology
|
| Internet Access |
|
| Collation |
online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
Heat Shock Proteins -- Small Heat Shock Proteins and the Cytoskeleton -- The Role of Hsps in Neuronal Differentiation and Development -- Heme Oxygenase as a Therapeutic Funnel in Nutritional Redox Homeostasis and Cellular Stress Response -- Heat Shock Proteins and the Regulation of Apoptosis -- Assembly of Protein Aggregates in Neurodegeneration -- The Role of Heat Shock Proteins during Neurodegeneration in Alzheimer's, Parkinson's and Huntington's Disease -- Heat Shock Proteins in Multiple Sclerosis. eat shock proteins (HSPs), also called stress proteins, are not only induced in response to elevated temperatures, but also as a result of various stress situations, including environmental strains, viral H infection, ischemia, anoxia and oxidative stress. These stress situations trigger cellular defence mechanisms that act as an emergency system capable of combatting the toxic consequences due to the accumulation of misfolded proteins. Heat shock proteins are involved in many physiological processes, including development and differentiation, organisation of the cytoarchi tecture by binding to cytoskeletal elements and regulation of the balance between cell death and survival. Many heat shock proteins work as molecular chaperones. In this role, they contribute to in vivo protein folding and prevent nonproductive interactions with other proteins and cellular c- ponents. In recent years it has been found that the chaperone system and the proteolytic machinery work closely together, and that proteasomal - hibition causes the upregulation of stress proteins. Impairment of the proteasomal machinery and chaperone functions lead to protein damage, which contributes to neurodegenerative disorders and to the aging process. |
| Place Published |
New York, NY |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Title Ser Add Ent |
Neuroscience Intelligence Unit |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2009 |
| Series Title Untraced |
Neuroscience Intelligence Unit |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20140517225649 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
03272nam a22004935i 45 |
