| Main Title |
Preliminary Report on the Concentration Time Response Relationships for Hydrogen Fluoride with Attachments and Cover Letter dated 06/21/88. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
28 Jun 1988 |
| Year Published |
1988 |
| Report Number |
FYI-OTS-0788-0607; |
| Stock Number |
OTS-0000607-1 |
| Additional Subjects |
Hydrogen fluoride ;
Toxicity tests ;
Exposure time ;
Concentration ;
Lethality ;
LC50 ;
Relative humidity ;
Rats ;
Health effects ;
Respiratory distress ;
DuPont(Tradmark)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000607-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
29p |
| Abstract |
The acute toxicity of hydrogen fluoride (HF) was evaluated in a series of experiments to determine the relationships between exposure time, HF concentration and lethality. Groups of 4 male Crl:CD(trademark)BR rats (approx. 200-300 g) were inserted into a 23 L Lucite(trademark) exposure chamber and exposed head-only to atmospheres of HF for periods of 5, 15, 30 or 60 minutes. Exposures were initially conducted with gaseous HF (2% HF in nitrogen) but due to the limited commercial availability of 2% HF, further exposures were performed using liquefied anhydrous HF. Anhydrous HF was diluted in either dry (les than 10% relative humidity) or humid (40-60% relative humidity) air. Gas samples were collected from the exposure chamber using tandem midget impingers and fluoride concentrations were measured with a fluoride ion selective electrode. Although body weights and clinical signs of toxicity were recorded during a 2-week recovery period, lethality was the primary endpoint for these studies. Mortality data were obtained from 6-15 exposures per time point and LC50 values were calculated by probit analysis. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
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| Category Codes |
57Y; 57U; 57B; 68G; 99D |
| NTIS Prices |
PC A03/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019102900 |
| Origin |
NTIS |
| Type |
CAT |
