| Main Title |
Study Report on Inhalation Median Lethal Concentration (LC50) with Cover Letter and EPA Responses dated 03/26/83. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Wilmington, DE.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
25 Nov 1981 |
| Year Published |
1981 |
| Report Number |
FYI-OTS-1183-0266-SU; |
| Stock Number |
OTS-0000266-1 |
| Additional Subjects |
Rats ;
Inhalation ;
Vapors ;
Aerosols ;
LC50 ;
O-toluidine ;
Lethal concentrations ;
Head only exposure
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000266-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
26p |
| Abstract |
Groups of 8-week old Crl: CD (tradename) male rats were exposed, head-only, to atmospheres of o-toluidine for single 4-hours periods. The LC50(sup double star) was determined to be 862 ppm with 95% confidence limits between 816 and 913 ppm. Compound-related clinical signs observed during and immediately following exposure consisted of tremors, slight to moderate cyanosis, muscle spasms, labored breathing, slight to moderate corneal opacity, prostration and semi-prostration, and reddish-brown nasal discharge. Clinical signs observed at 24 hours or longer consisted of corneal opacity, prostration, lethargy, labored breathing, pallor, hypothermia, reddish-brown nasal discharge, and stained-wet perinea. Weight losses of 6 to 22% were observed 1 to 3 days post-exposure, with normal weight gains occurring thereafter. The clinical manifestations of o-toluidine were generally dose-related. Deaths occurred with 1 to 4 days post-exposure. Time to death generally decreased as exposure concentrations increased. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A03/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010000270 |
| Origin |
NTIS |
| Type |
CAT |
