| Main Title |
2-chlorotoluene Metabolism by Rats with Cover Letter dated 01/14/1983. |
| CORP Author |
Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1983 |
| Report Number |
40-8335077 |
| Stock Number |
OTS0507452 |
| Additional Subjects |
Toxicology ;
Health effects ;
2-chlorotoluene ;
Pharmaco Kinetics ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 95-49-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0507452 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
21p |
| Abstract |
Absorption and metabolism of 2-chlorotoluene was examined in four female and four male Sprague-Dawley albino rats administered a single, oral 1 mg/kg bw dose of (U-ring-14C)2-chlorotoluene by gavage. Following administration, 2-chlorotoluene was rapidly absorbed; near complete elimination of the dose occurred within four days. No significant sex-related differences in metabolism of the test compound were found between males and females. A total of 85-92%, 5-8%, and 1-4% of the applied 14C were excreted in the urine, feces, and expired air, respectively. The primary urinary metabolites were 2-chlorobenzoic acid, a glucuronide of 2- chlorobenzyl alcohol, and a mercapturic acid, representing 20-23, 35-42, and 21-28% of the urinary 14C, respectively. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1983 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801190 |
| Origin |
NTIS |
| Type |
CAT |
