||NMDA (N-Methyl-D-Aspartate) receptor, antagonist, MK-801, suppresses limbic kindling and kindled seizures /
Gilbert, M. E.
||Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
|| U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||12 pages : illustrations ; 28 cm
||The role of excitatory amino acid neurotransmission in electrical kindling was examined in animals stimulated daily in the amygdala following ip administration of low dosages of MK-801 (0.1 and 0.5 mg/kg). A second experiment evaluated the anticonvulsant properties of MK-801 in rats kindled in the hippocampus and amygdala, and contrasted its efficacy with the antiepileptic agents diazepam, phenobarbital and phenytoin, and the dissociative anesthetics phencyclidine and ketamine. MK-801 (0.5 mg/kg) retarded the development of amygdala kindling and reduced mean afterdischarge (AD) duration over the first 10 stimulation sessions. The low dosage reduced total AD accrued during each kindling stage but failed to alter kindling rate. MK-801 blocked motor seizures induced by stimulation of hippocampal or amygdala kindled foci, but was more effective in reducing seizure severity and AD duration resulting from stimulation of the hippocampal focus. All other drugs tested, with the exception of phenytoin, protected against amygdaloid kindled seizures. It was concluded that excitatory amino acid transmission contributes in an important, but noncritical way to amygdala kindling. (Copyright (c) 1988 Elsevier Science Publishers B.V. (Biomedical Division).)
||Includes bibliographical references. Microfiche.
||Research Triangle Park, NC :
||Pub. in Brain Research, v463 p90-99 1988. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|Corporate Au Added Ent
||United States. Environmental Protection Agency. Office of Research and Development. ; Health Effects Research Laboratory
||NMDA receptor, anagonist, MK-801, suppresses limbic kindling and kindled seizures.
|PUB Date Free Form
||PC A03/MF A01
|OCLC Time Stamp
|OCLC Rec Leader
||01099cam 2200229Ka 45170