||Liver Metabolism of Anticholinesterase Compounds in Live Rats: Relation to Toxicity.
Gaines, Thomas B. ;
Hayes, Jr., Wayland J. ;
Linder., Ralph E. ;
||Communicable Disease Center, Atlanta, Ga.
Cholinesterase inhibitors ;
Laboratory animals ;
Experimental data ;
Chlorine organic compounds ;
Parenteral infusions ;
Body weight ;
Phosphorus organic compounds ;
DDVP insecticide ;
Toxic substances ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||To test the effect of a single pass through the liver, 'Isolan' was injected directly into the hepatic portal system (intestinal vein) in one group of rats and into the general circulation (femoral vein) in another group. Simlar investigations were conducted with two organic phosphorus compounds-dichlorvos, a direct inhibitor of cholinesterase, and parathion, an indirect inhibitor. It is well known that prathion is converted to the highly toxic paraoxon in the liver, but it is presumably in the liver also that it is eventually detoxified. Even though other techniques will have to be used to explain fully the pattern of toxicity of 'Isolan' when given by different routes, the technique presented in this report is a useful and relatively simple procedure for learning the net effect of the liver on the metabolism of chemicals in intact laboratory animals.
||Pub. in Nature, v209 n5018 p88-89, 1 Jan 66.
||Included in the report, Journal Articles on Toxicology, Group 15, PB-280 879.
||Reprint: Liver Metabolism of Anticholinesterase Compounds in Live Rats: Relation to Toxicity,
|PUB Date Free Form
||6T; 57Y; 68E; 68G
||(Order as PB-280 879, MF A01)