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Main Title Enhanced Mortality and Liver Damage in Virus-Infected Mice Exposed to p-Xylene.
Author Selgrade, M. K. ; Daniels, M. J. ; Jaskot, R. H. ; Robinson, B. L. ; Allis, J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Immunotoxicology Branch. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-94/047;
Stock Number PB94-137072
Additional Subjects Xylenes ; Liver ; Toxicity ; Mortality ; Virus diseases ; Mice ; Cytochrome P-450 ; Cytomegaloviruses ; Aspartate aminotransferase ; Alanine aminotransferase ; Body weight ; Organ weight ; Lactate dehydrogenase ; Isoenzymes ; Blood chemical analysis ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB94-137072 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
Abstract This study assessed effects of exposure to p-xylene, a ubiquitous air pollutant, on mice infected with murine cytomegalovirus (MCMV), a mouse model for a common human virus. Mice were exposed to filtered air, 600 or 1,200 ppm p-xylene 6 h/d for 4 d and infected with a sublethal dose of MCMV after the first exposure. No deaths occurred among uninfected, p-xylene-exposed mice or infected, air-exposed mice; 34% and 0% mortality occurred respectively in infected mice exposed to 1,200 and 600 ppm p-xylene. Virus titers in the liver and splenic natural killer cell activity were unaffected by exposure to 1,200 ppm p-xylene. MCMV significantly suppressed and p-xylene significantly increased total P-450 levels in the liver, but there was no significant interaction between the two Isozymes 1A1, 2B1/B2, and 2E1 were decreased to a similar degree, suggesting that the virus does not target specific isozymes. Enhanced mortality was not due to immune suppression. While p-xylene potentiated liver damage was caused by the virus, the magnitude of serum enzyme activities indicates that this damage was not a likely cause of death.
Supplementary Notes Pub. in Jnl. of Toxicology and Environmental Health, v40 n1 p129-144 Sep 93. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Enhanced Mortality and Liver Damage in Virus-Infected Mice Exposed to p-Xylene.
Category Codes 57Y; 57K; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 407719928
Origin NTIS
Type CAT