| Main Title |
Increased Susceptibility to Pentobarbital Following Mouse Cytomegalovirus Infection: Relative Roles of Viral-Induced Interferon and Viral Infection of the Liver. |
| Author |
Catignani, J. C. ;
Menache, M. G. ;
Selgrade, M. K. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div. ;North Carolina Univ. at Chapel Hill. School of Public Health. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/D-90/039; |
| Stock Number |
PB90-221714 |
| Additional Subjects |
Liver diseases ;
Toxicology ;
Pentobarbital ;
Mice ;
Antibodies ;
Graphs(Charts) ;
Enzyme inhibitors ;
Reprints ;
Cytomegalic inclusion disease ;
Interferon ;
Cytomegaloviruses ;
Disease susceptibility ;
Cytochrome P-450
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-221714 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The purpose of the study was to determine the relative roles of viral-induced interferon (IFN) and viral infection of the liver in mouse cytomegalovirus (MCMV)-induced depression of cytochrome P-450 (cyt P-450) levels and enhancement of pentobarbital-induced sleeping time (PEN-ST). This was done by establishing the temporal relationship among the IFN response, viral infection of the liver, suppression of cyt P-450 levels, and enhancement of PEN-ST, by determining the effect of anti-IFN antibody treatment on all of these responses, and by manipulating factors known to influence viral pathogenesis and host response to virus such as animal age, virulence of the virus, and dose of virus. (Copyright (c) 1989 VCH Publishers, Inc.) |
| Supplementary Notes |
Pub. in Jnl. of Biochem Toxicology, v4 n4 p221-228 1989. Prepared in cooperation with North Carolina Univ. at Chapel Hill. School of Public Health, and Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Increased Susceptibility to Pentobarbital Following Mouse Cytomegalovirus Infection: Relative Roles of Viral-Induced Interferon and Viral Infection of the Liver. |
| Category Codes |
57Y; 57E |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
021118167 |
| Origin |
NTIS |
| Type |
CAT |
