Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 1319 OF 1511

Main Title Studies on the Percutaneous Absorption of Parathion and Paraoxon. V. Rate of Absorption of Paraoxon.
Author Fredriksson., Torsten ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1961
Stock Number PB-280 010
Additional Subjects Pesticides ; Insecticides ; Toxicology ; Enzymes ; Cholinesterase inhibitors ; Dosage ; Responses ; Parenteral infusions ; Absorption(Biology) ; Skin(Anatomy) ; Cats ; Bioassay ; Laboratory animals ; Reprints ; Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester)
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB-280 010 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 4p
Abstract The rate of percutaneous absorption of paraoxon (E 600, or diethyl 4-nitrophenyl phosphate) has been determined by dose-response comparison following this mode of administration and intravenous infusion in the cat. The rate of inhibition of plasma cholinesterase activity was chosen as the parameter. Under the conditions of the study, the rate of percutaneous absorption was found to be constant in a given skin. By extrapolation from the activity curves, it was possible to determine the time required for paraoxon to diffuse from the topical deposit to the blood stream. This latency period was found to be approximately 12 minutes.
Supplementary Notes Pub. in Jnl. of Investigative Dermatology, v38 n4 p233-236, Apr 62.
Availability Notes Included in the report, Journal Articles on Toxicology. Group 11, PB-280 001.
Title Annotations Reprint: Studies on the Percutaneous Absorption of Parathion and Paraoxon. V. Rate of Absorption of Paraoxon,
PUB Date Free Form 27 Apr 61
Category Codes 6T; 57Y; 68G; 68E
NTIS Prices (Order as PB-280 001, MF A01)
Primary Description 500/01
Document Type NT
Cataloging Source NTIS/MT
Control Number 323739424
Origin NTIS
Type CAT