| Main Title |
Cardiovascular Effects of o,p'-DDD. |
| Author |
Cueto, Jr., Ciprian ;
|
| CORP Author |
National Communicable Disease Center, Perrine, Fla. Pesticides Research Lab. |
| Year Published |
1968 |
| Stock Number |
PB-278 082 |
| Additional Subjects |
Toxicology ;
Pesticides ;
Ingestion(Biology) ;
Dogs ;
Laboratory animals ;
Experimental data ;
Physiological effects ;
Cardiovascular system ;
Bioassay ;
Reprints ;
DDD insecticide ;
Toxic substances ;
Glucocorticoids
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-278 082 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1p |
| Abstract |
Daily oral administration of o,p'-DDD to dogs produced glucocorticoid deficiency. This was demonstrated by a decreased plasma hydroxy corticosteroids (17 OHCS) and the abolition of ACTH-induced increase in 17 OHCS and decrease of eosinophiles. Plasma volume, Na+, K+, and blood pressure and heart rate were unaltered. After two weeks of treatment with o,p'-DDD the dogs were anesthetized for pharmacological evaluation. Blood pressure and heart contractile force and rate responses to graded doses of epinephrine and norepinephrine were determined in treated and in untreated dogs. As a final test, cardiac contractile force response to ouabain was determined. |
| Supplementary Notes |
Pub. in Industrial Medicine and Surgery, 37(7) p520, Jul 68. |
| Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 3, PB-278 081. |
| Title Annotations |
Reprint: Cardiovascular Effects of o,p'-DDD, |
| PUB Date Free Form |
1968 |
| Category Codes |
6T; 6F; 57Y; 68G; 68E |
| NTIS Prices |
(Order as PB-278 081, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323735749 |
| Origin |
NTIS |
| Type |
CAT |
