| Main Title |
Rat Oral Subchronic Toxicity Study. Compound: Isobutyl Alcohol. |
| Author |
Tompkins, E. C. ;
|
| CORP Author |
Research Triangle Inst., Research Triangle Park, NC. ;Toxicity Research Labs. Ltd., Muskegon, MI.;Environmental Protection Agency, Washington, DC. Office of Solid Waste. |
| Year Published |
1987 |
| Report Number |
EPA-68-01-7075; EPA/530/SW-88/015; |
| Stock Number |
PB88-176177 |
| Additional Subjects |
Toxicology ;
Bioassay ;
Rats ;
Laboratory animals ;
Ingestion(Biology) ;
Dosage ;
Isobutyl alcohol ;
Teratogenesis ;
CAS 78-83-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-176177 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
390p |
| Abstract |
The purpose of the study was to evaluate the toxicity of isobutyl alcohol in a rat subchronic toxicity study. Four groups of male and female rats (30/sex/group) were dosed orally once daily with 0, 100, 316, or 1000 mg/kg/day of compound until the day of necropsy at an interim sacrifice (days 29 and 30) or a final sacrifice (days 92 and 93). Oral administration of isobutyl alcohol produced treatment-related effects at a dose level of 1000 mg/kg/day, but not at dose levels of 100 or 316 mg/kg/day. At the 1000 mg/kg/day dose level, hypoactivity was observed in all rats and body weight gain in the males was 18% below the control average during week 1. Food consumption averages were below those of the controls for both males and females during weeks 1 and 2. In addition, serum potassium averages were 11-15% below control averages (both sexes) at the interim evaluation and this may have been a small transitory effect related to treatment. |
| Supplementary Notes |
Also pub. as Toxicity Research Labs., Ltd., Muskegon, MI. rept. no. TRL/STUDY-032-002. Prepared in cooperation with Toxicity Research Labs. Ltd., Muskegon, MI. Sponsored by Environmental Protection Agency, Washington, DC. Office of Solid Waste. |
| NTIS Title Notes |
Final rept.. |
| PUB Date Free Form |
Oct 87 |
| Category Codes |
57Y#; 57O |
| NTIS Prices |
PC A17/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
811328185 |
| Origin |
NTIS |
| Type |
CAT |
