| Main Title |
Infectivity and pathogenicity of enteroviruses ingested with drinking water / |
| Author |
Cliver, Dean O.,
|
| CORP Author |
Wisconsin Univ.-Madison. Food Research Inst.;Health Effects Research Lab., Cincinnati, OH. |
| Publisher |
Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory ; |
| Year Published |
1980 |
| Report Number |
EPA-600/1-80-005 |
| Stock Number |
PB80-150626 |
| OCLC Number |
06275032 |
| Subjects |
Drinking water--Contamination ;
Enteroviruses
|
| Additional Subjects |
Potable water ;
Enteroviruses ;
Public health ;
Ingestion(Biology) ;
Pathology ;
Infectious diseases ;
Water supply ;
Models ;
Water pollution ;
Tissue culture ;
Drinking water
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-80-005 |
c.1 |
Headquarters Library/Washington,DC |
04/28/2014 |
| ELBD ARCHIVE |
EPA 600-1-80-005 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-1-80-005 |
|
AWBERC Library/Cincinnati,OH |
02/08/2008 |
| NTIS |
PB80-150626 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
vii, 29 pages ; 28 cm. |
| Abstract |
The study was designed to examine the relationship of waterborne enteroviruses to infections and disease. Young weanling swine and their homologous enteroviruses were chosen as the model system: The porcine digestive tract is like that of man, but pigs can be handled under more closely standardized conditions than humans or other primates. Known quantities of two enteroviruses were administered in 5 ml of drinking water in such a way that the subjects were obliged to swallow all of it. The intact animal was found to be about 1000 times (600 to 750 for one virus and 1800 to 2500 for the other) less likely than the tissue cultures to be infected by a given quantity of enterovirus. The ratio did not depend on whether the animals were fed just before challenge. The probability of infection was cumulative with iterated small doses: this indicated that there was, in the strict sense, no minimum infectious dose. None of the infected animals became ill, despite the reported virulence of the challenge viruses. Chlorine treatment of a concentrated virus suspension, which reduced infectivity to a level detectable by cytopathic effect but not plaque formation in tissue culture, left enough virus to infect one of five challenged subjects. Neither of two colostrum-deprived pigs, challenged by stomach tube with 20 plaque-forming units of enterovirus at one and one half hr of age, became infected. |
| Notes |
"January 1980." "Grant Number R803986." "Project Officer Elmer W. Akin, Water Quality Division." "Food Research Institute and World Health Organization Collaborating Centre on Food Virology, University of Wisconsin-Madison." Includes bibliographical references (pages 27-28). |
| Place Published |
Cincinnati, Ohio Springfield, Va. |
| Access Notes |
Also issued online. |
| Corporate Au Added Ent |
Health Effects Research Laboratory (Cincinnati, Ohio); University of Wisconsin--Madison. Food Research Institute.; World Health Organization. Collaborating Centre on Food Virology. |
| Title Ser Add Ent |
Research reporting series. Environmental health effects research ; EPA-600/1-80-005. |
| PUB Date Free Form |
1980 |
| Series Title Traced |
Research reporting series Environmental health effects research ; EPA-600/1-80-005 |
| Series Title Untraced |
Research reporting series. 1, Environmental health effects research ; EPA-600/1-80-005 |
| NTIS Prices |
PC A03/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| Merged OCLC records |
13594346; 1225691440 |
| OCLC Time Stamp |
20140423145641 |
| Language |
eng |
| SUDOCS Number |
EP 1.23/4:600/1-80-005 |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
02487cam 2200493Ia 45020 |
