Main Title |
Cellular Pathology of a Granulosis Virus Infection. |
Author |
Walker, Susan ;
Kawanishi, C. Y. ;
Hamm, J. J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1982 |
Report Number |
EPA-600/J-81-391; |
Stock Number |
PB83-213892 |
Additional Subjects |
Viral diseases ;
Infectious diseases ;
Pathology ;
Cells(Biology) ;
Reprints ;
Spodoptera frugiperda ;
Granulosis viruses
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB83-213892 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
Nuclear and cytoplasmic ultrastructural changes were examined in Spodoptera frugiperda (SF) larval fat body cells infected with granulosis virus (GV). Soon after infection necleocapsidlike structures were observed within the nucleus associated with nuclear pores. The earliest cellular alterations were the formation of intra-nuclear membrane blebs and annulate lamellae. There was also development of nuclear envelope associated crystals, followed by coalescence of heterochromatin, nucleoplasm clearing, loss of nuclear envelope integrity, paired cisternae formation, and virus assembly. Stored lipid decreased and glycogen was depleted. Mitochondria assumed a condensed configuration. Gap junctions, desmosomes, and hemidesmosomes normally present in uninfected fat body cells were lost during infection. Infected cells appeared to detach from other cells and basal lamina; concomitantly, mitotic activity was observed more frequently in peripheral uninfected cells within proximity of the delimiting fat body basal lamina than in controls. Such changes may help to explain previous observations of a proliferative response to GV infection and consequent fat body hyperplasia. |
Availability Notes |
Pub. in Jnl. of Ultrastructure Research 80, p163-177 1982. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Cellular Pathology of a Granulosis Virus Infection. |
PUB Date Free Form |
c1982 |
Category Codes |
6C; 57F |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
325919010 |
Origin |
NTIS |
Type |
CAT |