| Main Title |
Dose-Response Fallacy in Human Reproductive Studies of Toxic Exposures. |
| Author |
Selevan, S. G. ;
Lemasters, G. K. ;
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Reproductive Effects Assessment Group. ;National Inst. for Occupational Safety and Health, Cincinnati, OH. ;Cincinnati Univ., OH. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/271; |
| Stock Number |
PB88-177183 |
| Additional Subjects |
Toxicology ;
Reproduction(Biology) ;
Industrial medicine ;
Dosage ;
Responses ;
Humans ;
Exposure ;
Reprints ;
Occupational safety and health
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-177183 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The manner in which exposure is defined can affect the findings of reproductive studies of toxic exposures. The individual end points potentially examined, such as fetal loss, subfertility, and congenital malformations observed at birth, are on a continuum by severity of effect: the most extreme effects of the three being infertility because no pregnancy is possible, and the least extreme, congenital malformations recognized at birth. End points observed at birth are survivors of a long and complex process. The process yielding one of these adverse end points may result from a number of factors, including level of exposure could result in early fetal loss, whereas a lower one might result in a congenital malformation observed at birth. If the probability of a less severe end point falls due to increasing probability of more severe end points with increasing exposure, then a nontraditional dose-response relationship may be observed in the study of one type of outcome. |
| Supplementary Notes |
Pub. in Jnl. of Occupational Medicine, v29 n5 p451-454 May 87. Prepared in cooperation with National Inst. for Occupational Safety and Health, Cincinnati, OH., and Cincinnati Univ., OH. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Dose-Response Fallacy in Human Reproductive Studies of Toxic Exposures. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57Y; 57U; 68G |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
812726831 |
| Origin |
NTIS |
| Type |
CAT |
