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Main Title Absence of Mutagenicity in the Urine of Autopsy Service Workers Exposed to Formaldehyde: Factors Influencing Mutagenicity Testing of Urine.
Author Connor, T. H. ; Ward, J. B. ; Legator, M. S. ;
CORP Author Texas Univ. Medical Branch at Galveston.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-807548; EPA/600/J-85/403;
Stock Number PB86-204641
Additional Subjects Industrial medicine ; Histidine ; Reprints ; Formaldehyde ; Occupational safety and health ; Mutagenesis ; Urinalysis ; Autopsies
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NTIS  PB86-204641 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Abstract The study examined the effect of exposure to autopsy workers to formaldehyde using urinary mutagenicity testing with Salmonella typhimurium. A matched control group was also studied. Additional studies including the recovery of histidine from urine samples, the determination of histidine in urine samples and the effect of exogenous and urinary histidine on the mutagenicity assay were also carried out. Results showed that there was no increase in mutagenicity in the autopsy workers as compared to the control group. A large proportion of the exposed individuals had toxic urine while only two of the control group has similar toxic urine. However, the toxic material in the urine samples has been isolated and does not appear to be related to the formaldehyde exposure. In conclusion, exogenous histidine and certain growth factors present in human urine can affect the outcome of both plate incorporation and fructuation assays for mutagenicity and care must be taken when interpreting results of this type of mutagenicity studies.
Supplementary Notes Pub. in International Archives of Occupational and Environmental Health 56, p225-237 1985. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Absence of Mutagenicity in the Urine of Autopsy Service Workers Exposed to Formaldehyde: Factors Influencing Mutagenicity Testing of Urine.
PUB Date Free Form c1985
Category Codes 6J; 57U; 68G
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 621324583
Origin NTIS
Type CAT