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Main Title Glucocorticoid Receptor Expression during the Development of the Embryonic Mouse Secondary Palate.
Author Abbott, B. D. ; McNabb, F. M. A. ; Lau, C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;Virginia Polytechnic Inst. and State Univ., Blacksburg. Dept. of Biology.
Publisher cMay 94
Year Published 1994
Report Number EPA/600/J-94/513;
Stock Number PB95-148755
Additional Subjects Glucocorticoid receptors ; Cleft palate ; Embryo development ; Animal pregnancy ; Messenger RNA ; In situ hybridization ; Immunohistochemistry ; Developmental gene expression regulation ; Northern blotting ; Cell differentiation ; Reprints ;
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NTIS  PB95-148755 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Abstract Glucocorticoids are known to be teratogenic, and administration of these compounds during pregnancy produces cleft palate in the offspring. In the mouse, induction of cleft palate correlates with the level of palatal glucocorticoid receptor (GR) expression. In the present study, GR expression was evaluated in the developing palates of C57BL/6N mouse embryos on gestation days (GD) 12, 13, 14, and 15 by both in situ hybridization and immunohistochemistry. Chondrogenic regions strongly expressed GR. In different regions of oral and nasal epithelia localized patterns of expression were noted and may be related to differentiated state. Correspondingly, GR mRNA was expressed in epithelia and became regional in mesenchyme with abundant mRNA in regions of bone formation. GR localized initially within regions of active morphogenesis and subsequently within differentiating cells. This specificity of spatial and temporal expression supports the idea that GR is involved in regulation of regional growth and differentiation during palatogenesis.
Supplementary Notes Pub. in Jnl. of Craniofacial Genetics and Developmental Biology, v14 p87-96 May 94. Prepared in cooperation with Virginia Polytechnic Inst. and State Univ., Blacksburg. Dept. of Biology.
NTIS Title Notes Journal article.
Title Annotations Reprint: Glucocorticoid Receptor Expression during the Development of the Embryonic Mouse Secondary Palate.
Category Codes 57S; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 503415244
Origin NTIS
Type CAT