| Main Title |
Sulfolane-Induced Hypothermia Enhances Survivability in Mice. |
| Author |
Gordon, C. J. ;
Long, M. D. ;
Fehlner, K. S. ;
Dyer, R. S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/443; |
| Stock Number |
PB88-170931 |
| Additional Subjects |
Hypothermia ;
Survival ;
Thermoregulation ;
Mice ;
Body temperature ;
Physiological effects ;
Laboratory animals ;
Toxicology ;
Reprints ;
Sulfolane ;
Toxic substances
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-170931 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Mice injected intraperitoneally with sulfolane (tetrahydrothiophene-1, 1-dioxide) undergo a decrease in metabolic rate and body temperature. If given the opportunity, mice treated with sulfolane preferentially seek a cool ambient temperature. At a warm ambient temperature (35 C) neither metabolic rate nor body temperature are decreased by sulfolane. When given the LD50 dose of sulfolane, the percent mortality varies directly with ambient temperature. For example, at 35 C mortality is 75% whereas at 25 C mortality is only 8%. By undergoing an autonomically and behaviorally-mediated decrease in body temperature (i.e., regulated hypothermia), sulfolane-treated mice appear to enhance their chance of survival. |
| Supplementary Notes |
Pub. in Environmental Research, v40 p92-97 1986. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Sulfolane-Induced Hypothermia Enhances Survivability in Mice. |
| PUB Date Free Form |
1986 |
| Category Codes |
68G; 57Z; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
812722666 |
| Origin |
NTIS |
| Type |
CAT |
