Full Record Display for the EPA National Library Catalog
RECORD NUMBER: 12 OF 22| Main Title | Evidence for Effects of Chronic Lead Exposure on Blood Pressure in Experimental Animals: An Overview. | |||||||||||
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| Author | Victery, W. ; | |||||||||||
| CORP Author | Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. | |||||||||||
| Year Published | 1988 | |||||||||||
| Report Number | EPA/600/D-88/018; | |||||||||||
| Stock Number | PB88-170097 | |||||||||||
| Additional Subjects | Lead(Metal) ; Blood pressure ; Reviews ; Exposure ; Hypertension ; Models ; Toxicology ; Laboratory animals ; | |||||||||||
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| Collation | 18p | |||||||||||
| Abstract | Information obtained in a number of experimental studies conducted over the last forty years on the effects of lead on blood pressure is reviewed. Differences in animal species, age at beginning of exposure, level of lead exposure, indices of lead burden, and blood pressure effects of each study are reported. In several of the high-dose experiments, hypertension was observed, but nephrotoxicity of lead may have contributed to its development. Moreover, in other high-dose experiments, no hypertension was observed and in at least one, the evidence suggested that lead could reduce an elevated blood pressure. In contrast, the lower-dose experiments consistently demonstrated a hypertensive effect. Overall, the data suggest a biphasic dose response. | |||||||||||
| NTIS Title Notes | Symposium paper. | |||||||||||
| PUB Date Free Form | Jan 88 | |||||||||||
| Category Codes | 57Y; 57S; 68G | |||||||||||
| NTIS Prices | PC A03/MF A01 | |||||||||||
| Primary Description | 600/21 | |||||||||||
| Document Type | NT | |||||||||||
| Cataloging Source | NTIS/MT | |||||||||||
| Control Number | 812722292 | |||||||||||
| Origin | NTIS | |||||||||||
| Type | CAT |