||Effects of Exposure to Ozone on Susceptibility to Experimental Tuberculosis.
Thomas, Gail ;
Fenter, James ;
Ehrlich, R. ;
Gardner, D. E. ;
||IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Guinea pigs ;
Mycobacterium tuberculosis ;
Air pollution effects(Animals)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Exposure of mice to 1.96 mg/cu. m. ozone (03) 3 h/day, 5 days/week, for up to 8 weeks beginning at 1 or 2 weeks after challenge with Mycobacterium tuberculosis R1Rv resulted in significant enhancement of bacterial titers in the lungs at 5 through 8 weeks after challenge when compared to mice compared to controls. Exposure of guinea pigs to 2.9 mg/cu. m 03 for 3 h immediately after challenge with M. tuberculosis resulted in a suppression of the cutaneous delayed hypersensitivity response, without affecting the serum hemagglutination antibody titers. However, exposure of guinea pigs to 0.98 mg/cu. m 03 3h/day for 5 days, initiated within 3 h after the infectious challenge, enhanced hemagglutination antibody titers initially, but the delayed hypersensitivity reaction did not differ from controls.
||Pub. in Toxicology Letters, v9 p11-17 1981.
|NTIS Title Notes
||Reprint: Effects of Exposure to Ozone on Susceptibility to Experimental Tuberculosis.
|PUB Date Free Form
||6T; 6F; 57Y; 68A
||Not available NTIS