| Main Title |
Initial Submission: TKA 40207, Contact Hypersensitivity in Albino Guinea Pigs Maximization Test, with Cover Letter dated 11/03/99 (Sanitized). |
| CORP Author |
CIBA Specialty Chemical Corporation ;RCC, Ltd.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
4 Nov 1999 |
| Year Published |
1999 |
| Report Number |
8EHQ-1199-14582S; |
| Stock Number |
OTS-0559829 |
| Additional Subjects |
Toxicity ;
Guinea pigs ;
Females ;
Laboratory animals ;
Intradermal induction ;
Dosage ;
Skin reactions ;
Assessments ;
Contact hypersensitivity ;
Cutaneous allergenic potentials ;
TKA 40207 ;
Maximization-Test
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0559829 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
57p |
| Abstract |
In order to assess the cutaneous allergenic potential of TKA 40207 the Maximization-Test was performed in 15 (10 test and 5 control) female albino guinea pigs, in accordance with OECD Guideline No. 406 and the Directive 96/54/EEC, B.6. The intradermal induction of sensitization in the test group was performed with a 5 % dilution of the test article in acetone/olive oil (l:1, v/v) and in an emulsion of Freund's Complete Adjuvant (FCA) / physiological saline. The epidermal induction of sensitization was conducted under occlusion with the test article at 25 % in acetone/olive oil (1:1, v/v) one week after the intradermal induction. The animals of the control group were intradermally induced with acetone/olive oil (l:1, v/v) and FCA/physiological saline and epidermally induced with acetone/olive oil (1:1, v/v) under occlusion. Two weeks after epidermal induction the control and test animals were challenged by epidermal application of the test article at 5 % in acetone/olive oil (l:1, v/v) and acetone/olive oil (1:1, v/v) alone under occlusive dressing. Cutaneous reactions were evaluated at 24 and 48 hours after removal of the dressing. |
| Supplementary Notes |
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| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57Y |
| NTIS Prices |
PC A05/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019101950 |
| Origin |
NTIS |
| Type |
CAT |
