| Main Title |
Trophic Control of the Ornithine Decarboxylase/Polyamine System in Neonatal Rat Brain Regions: Lesions Caused by 6-Hydroxydopamine Produce Effects Selective for Cerebellum. |
| Author |
Lau, C. ;
Cameron, A. ;
Antolick, L. ;
Slotkin, T. A. ;
|
| CORP Author |
Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/049; |
| Stock Number |
PB90-217464 |
| Additional Subjects |
Biochemistry ;
Polyamines ;
Cerebellum ;
Graphs(Charts) ;
Body weight ;
Norepinephrine ;
Reprints ;
Ornithine decarboxylase ;
Hydroxydopamines ;
Newborn animals ;
Organ weight
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-217464 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Norepinephrine has been hypothesized as a trophic factor influencing postnatal development of the cerebellum. In the current study, neonatal rats were given 6-hydroxydopamine (6-OHDA) to destroy noradrenergic projections and the effects on the ornithine decarboxylase (ODC)/polyamine system were evaluated; ODC initiates the synthesis of polyamines, which are known to control cellular development in the cerebellum, and neonatal ODC activity is regulated in part by B2-adrenergic receptors. Intracisternal administration of 6-OHDA resulted in complete and permanent depletion of cerebellar norepinephrine and a deficit in ODC, polyamine levels and cerebellar growth. Subcutaneous administration of 6-OHDA, which caused only a small initial reduction in cerebellar norepinephrine, did not affect ODC and had only minor effects on tissue growth. Indeed, levels of the polyamines tended to be elevated after subcutaneous 6-OHDA, associated with postweaning elevations in norepinephrine, results which are probably indicative of axonal regeneration. (Copyright (c) 1990 Elsevier Publishers BV (Biomedical Division).) |
| Supplementary Notes |
Pub. in Developmental Brain Research, v52 p167-173 Jan 90. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Trophic Control of the Ornithine Decarboxylase/Polyamine System in Neonatal Rat Brain Regions: Lesions Caused by 6-Hydroxydopamine Produce Effects Selective for Cerebellum. |
| Category Codes |
57B; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019411147 |
| Origin |
NTIS |
| Type |
CAT |
