| Main Title |
Initial Submission: Inhalation Pilot Study of Hydrogen Cyanide Exposure in Sprague-Dawley Rats with Cover Letter dated 07/23/92. |
| CORP Author |
Monsanto Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920007543 |
| Stock Number |
OTS0545731 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hydrogen Cyanide ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 74-90-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0545731 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
30p |
| Abstract |
Hydrocyanic acid (CAS No. 74-90-8) was evaluated for subacute inhalation toxicity in Sprague-Dawley rats (5/sex/group) administered whole-body exposures to a mean analytical concentration of 67.8 +/- 7.0 ppm for 6 hours on 3 consecutive days under dynamic conditions (2060-2200 L/min). An initial exposure was associated with hypoactivity, rapid shallow breathing, anoxia/hypoxia signs, and convulsions, followed by chromorhinorrhea, convulsions and varied signs of labored breathing. Survivors of 2 exposures exhibited rapid breathing and reduced mean bodyweight with a solitary male rat exhibiting arching of the back. Signs of toxicity associated with a third exposure were limited to hypoactivity and quick shallow breathing; mean daily bodyweight gains were restored. Mortality occurred either during or following an initial exposure in 1 and 2 males, respectively. Necropsy of these study decedents revealed cyanosis of the extremities, hemorrhagic lungs, lung and tracheal edema, blanching of the liver, chromorhinorrhea, urine-filled bladder, gaseous distention of the gastro-intestinal tract, and a solitary incidence of blood engorgement of the heart and surrounding vasculature. On terminal necropsy of study survivors, females exhibited slight to moderate hemorrhage (3/5) and grey discoloration (2/5) of the lung. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803690 |
| Origin |
NTIS |
| Type |
CAT |
