| Main Title |
Four-Week Oral Nephrotoxicity Screening Study in Male F344 Rats (Draft Report) with Cover Letter dated 10/25/85 and EPA Acknowledgement Letter. |
| CORP Author |
American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
Oct 1985 |
| Year Published |
1985 |
| Report Number |
FYI-AX-1085-0460; |
| Stock Number |
OTS-0000460-0 |
| Additional Subjects |
Rats ;
Environmental health ;
Public health ;
Toxicity ;
Gavage ;
Mortality ;
Body weight ;
Male F344 rats ;
Oral nephrotoxicity screening ;
Hydrocarbon materials ;
Gross pathology
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000460-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
126p |
| Abstract |
API PS-6-Fuel and 12 other hydrocarbon materials were administered by gavage to groups of 10 male Fischer 344 rats five days per week for four weeks. A dose level of 2.0 g/kg was used for each material. The dose level was approximate since doses throughout the study were calculated based on the initial body weight of each animal. In addition, a negative control group received 2.0 g/kg of saline during each phase. Animals were observed twice daily for mortality and clinical signs of toxicity; body weights were recorded at initiation and at the time of scheduled sacrifice. The potential nephro-toxic effects of the test articles were assessed through gross and microscopic pathology evaluations. 2, 2, 7, 7-Tetramethyloctaine could not be tested due to the insolubility of the compound. No deaths occurred in either the API-6-Fuel or the saline-treated groups. One rat treated with 3-Methyloctane died on Day 10. Three rats died in the Octaine-treated group, one on Day 10 and two on Day 22. No antemortem observations were noted. No significant test material-related clinical signs were observed during the study. A decrease in body weight at terminal sacrifice was seen in all groups except the 2, 2, 4, 4, 5, 5, 7, 7-Octamethyloctane treated group. The decrease in the Decane group was numerically lower. The most pronounced decrease was seen in the API PS-6-Fuel and 2, 2, 3,-Trimethyloctane treated groups. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57Y |
| NTIS Prices |
PC A08/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010001870 |
| Origin |
NTIS |
| Type |
CAT |
