Main Title |
Impairment of Calcium Homeostasis by Hexachlorobenzene (HCB) Exposure in Fischer 344 Rats (Journal Version). |
Author |
Andrews, J. E. ;
Courtney, K. D. ;
Donaldson, W. E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/061; |
Stock Number |
PB89-110332 |
Additional Subjects |
Calcium metabolism disorders ;
Toxicity ;
Calcitriol ;
Homeostasis ;
Cholesterol ;
Liver ;
Chlorohydrocarbons ;
Laboratory animals ;
Kidney ;
Parathyroid hormone ;
Reprints ;
Hexachlorobenzene ;
Alanine aminotransferase ;
Benzene/hexachloro ;
Vitamin D deficiency ;
Body weight
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-110332 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Human exposure to hexachlorobenzene (HCB) has resulted in demineralization of bone with osteoporosis resulting. Experiments were undertaken to investigate the effects of HCB on the homeostatic mechanism of calcium metabolism. Fischer 344 rats were dosed with 0, 0.1, 1.0, 10.0 or 25.0 mg HCB/kg body weight 5 days/wk for 5 wks while being fed normal rat diet or vitamin D3 deficient diet. Rats receiving the normal diet had a dose-related decrease in body weight gain and increased liver weight when compared to their controls. Serum cholesterol, alanine aminotransferase (ALT), 1,25-dihydroxy-vitamin D3 (1,25-(OH)2D) and parathyroid hormone (PTH) were significantly elevated when compared to control values. In the vitamin D3 deficient diet group, there was a dose related increase in liver weight, liver-to-body-weight ratio and kidney-to-body-weight ratio. Serum cholesterol and 1,25-(OH)2D were significantly elevated. The data indicate that HCB does affect calcium metabolism by altering the concentrations of two primary controlling factors in calcium homeostasis. (Copyright (c) 1988 by Hemisphere Publishing Corporation.) |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v23 p311-320 1988. Prepared in cooperation with North Carolina State Univ. at Raleigh. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Impairment of Calcium Homeostasis by Hexachlorobenzene (HCB) Exposure in Fischer 344 Rats (Journal Version), |
Category Codes |
57Y; 57U; 44G; 68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834424812 |
Origin |
NTIS |
Type |
CAT |