||Carcinoma of the Exocrine Pancreas in Medaka.
Fournie, J. W. ;
Hawkins, W. E. ;
Battalora, M. S. J. ;
Walker., W. W. ;
||Environmental Research Lab., Gulf Breeze, FL. ;Gulf Coast Research Lab., Ocean Springs, MS.
Water pollution effects(Animals) ;
Pancreatic neoplasms ;
Methylazoxymethanol acetate ;
Carcinogenicity tests ;
Peritoneal neoplasms ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Eight cases of acinar cell carcinoma of the exocrine pancreas were diagnosed in Japanese medaka (Oryzias latipes) from a pool of approximately 10,000 specimens used in a variety of carcinogenesis bioassays. Three cases occurred in specimens from control groups and one case in a specimen exposed to benzo(e)pyrene (BeP), a noncarcinogenic isomer of benzo(a)pyrene (BaP). Four cases occurred in specimens exposed to known carcinogens including two cases in specimens exposed to 7,12-dimethylbenz(a)anthracene (DMBA), one in a medaka exposed to benzo(a)pyrene, and one in a specimen exposed to methylazoxymethanol acetate (MAM-Ac). Pancreatic carcinoma was probably the cause of death in five cases. The neoplasms appeared to originate in the mesentery near the abdominal surface of the liver.
||Pub. in Jnl. of Aquatic Animal Health, v3 p213-220 1991. See also PB88-196266. Prepared in cooperation with Gulf Coast Research Lab., Ocean Springs, MS.
|NTIS Title Notes
||Reprint: Carcinoma of the Exocrine Pancreas in Medaka.
||68D; 57Y; 57E
||PC A02/MF A01