Main Title |
A short-term method for assessing the reproductive toxicity of endocrine-disrupting chemicals using the fathead minnow (Pimephales promelas) / |
Author |
Mid-Continent Ecology Division.
|
CORP Author |
National Health and Environmental Effects Research Lab., Duluth, MN. Mid-Continent Ecology Div. (Duluth) Library. |
Publisher |
National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Office of Research and Development, U.S. Environmental Protection Agency, |
Year Published |
2002 |
Report Number |
EPA/600-R-01-067 |
Stock Number |
PB2007-106215 |
OCLC Number |
50549562 |
Subjects |
Endocrine disrupting chemicals--Toxicology ;
Fathead minnow ;
Reproductive toxicology
|
Additional Subjects |
Reproductive toxicity ;
Assessment ;
Fathead minnow ;
Manuals ;
Test methods ;
Chemicals ;
Estrogens ;
Androgens ;
Endpoint ;
Reproductive behavior ;
Fecuncity ;
Fertility ;
Procedures ;
Measurements ;
Short-term test method ;
Endocrine-disrupting chemicals ;
Endocrine pathways ;
Adult survival ;
Secondary sex characteristics ;
Gonadosomatic ;
Gonadal histology ;
Plasma concentrations ;
Vitellogenin ;
Sex steroids
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600-R-01-067 |
|
Headquarters Library/Washington,DC |
11/18/2015 |
EKCD |
EPA/600/R-01/067 |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
08/12/2013 |
ELBD ARCHIVE |
EPA 600-R-01-067 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELDD |
EPA/600/R-01/067 |
|
CCTE/GLTED Library/Duluth,MN |
09/06/2002 |
NTIS |
PB2007-106215 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
xi, 154 pages : illustrations ; 28 cm |
Abstract |
This manual describes a test method with the fathead minnow suitable for assessing potential reproductive effects of chemicals, with an emphasis on endocrine pathways controlled by estrogens and androgens. The test is conducted with reproductively-mature animals for 21 d. Endpoints assessed include: adult survival, reproductive behavior, secondary sex characteristics, gonadosomatic index, gonadal histology, plasma concentrations of vitellogenin and sex steroids (beta-estradiol, testosterone, 11-ketotestosterone), fecundity, fertility, and if desired, F(sub 1) viability. In addition to describing the test method, guidance is presented as to interpretation of test results with respect to identifican of potential endocrine-disrupting chemicals. |
Notes |
"June 2002." Includes bibliographical references (pages 98-107). "EPA/600-R-01-067." Includes appendices "A-E" (p. 108-147). |
Place Published |
Duluth, MN |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
Corporate Au Added Ent |
National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, (Duluth, Minn.) |
PUB Date Free Form |
2002 |
Category Codes |
57Y |
NTIS Prices |
PC A09/MF A02 |
BIB Level |
m |
Medium |
unmediated |
Content |
text |
Carrier |
volume |
Cataloging Source |
OCLC/T |
Control Number |
019101430 |
OCLC Time Stamp |
20151112121937 |
Language |
eng |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
01504cam 2200337Ki 45020 |