Main Title |
Lethality and Hepatotoxicity of Complex Waste Mixtures (Journal Version). |
Author |
Simmons, J. E. ;
DeMarini, D. M. ;
Berman, E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/117; |
Stock Number |
PB89-109367 |
Additional Subjects |
Toxicity ;
Industrial wastes ;
Hazardous materials ;
Chemical analysis ;
Predictions ;
Montality ;
Exposure ;
Laboratory animals ;
Histology ;
Liver ;
Organ weight ;
Reprints ;
Liver function tests ;
Oral administration
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-109367 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
Male F344 rats were exposed by gavage to samples of complex mixtures and evaluated 24 hours later. Seven of the 10 samples caused death at doses ranging from 1 to 5 ml/kg body wt. Eight of the 10 samples were hepatotoxic based on histopathologic evaluation; 6 were centrilobular and 2 were periportal hepatotoxicants. The waste samples exerted toxicity through different mechanisms, as indicated by differences in the severity and lobular location of the tissue damage. With histopathological evaluation as the criterion, relative liver weight was the single best indicator of hepatotoxicity. Exposure to several of the waste samples increased serum total bilirubin and serum enzyme activities of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase, and ornithine carbamyl transferase. As a battery, but not individually, the serum indicators separated the 8 hepatotoxic samples from the 2 nonhepatotoxic samples. In general, the hepatotoxicity of the waste samples did not appear to be readily predicted from (partial) chemical characterization data. |
Supplementary Notes |
Pub. in Environmental Research, v46 p74-85 1988. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Lethality and Hepatotoxicity of Complex Waste Mixtures (Journal Version). |
Category Codes |
57Y; 57U; 68C; 68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834423993 |
Origin |
NTIS |
Type |
CAT |