Main Title |
Rapid Method for Estimating Log P for Organic Chemicals. |
Author |
Veith, G. D. ;
Austin, N. M. ;
Morris, R. T. ;
|
CORP Author |
Environmental Research Lab.-Duluth, MN. |
Year Published |
1978 |
Report Number |
EPA/600/J-79/001; |
Stock Number |
PB-292 532 |
Additional Subjects |
Organic compounds ;
Partition coefficient ;
Laboratory equipment ;
Standards ;
Calibrating ;
High pressure liquid chromatography ;
Procedures ;
Reprints
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-292 532 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
The logarithm of the retention time (log RT) of organic chemicals on a permanently bonded (C-18) reverse-phase high-pressure liquid chromatography system is shown to be linearly related to the logarithm of the n-octanol/water partition coefficient (log P). A rapid, inexpensive technique based on reverse-phase high-pressure liquid chromatography has been developed to estimate the n-octanol/water partition coefficient of organic chemicals. The system consists of a preparative Micro-Pak(R) C-10 reverse-phase column eluted with a 15% water/85% methanol solvent flowing at 2 ml/min at room temperature. A linear calibration of the logarithm of retention time with the logarithm of the partition coefficient (log P) is attained by using a mixture of benzene, bromobenzene, biphenyl, bibenzyl, p,p'DDE, and 2,4,5,2',5'-pentachlorobiphenyl as reference standards of known log P. Using a calibration mixture, the log P of other organic chemicals were estimated with a mean accuracy of 22.8% of the log P values reported in the literature. The technique permits estimation of log P in a maximum of 25 min and does not require a knowledge of the structure of the chemical for the estimate. |
Supplementary Notes |
Pub. in Water Research, v13, p43-47 1979. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: A Rapid Method for Estimating Log P for Organic Chemicals. |
PUB Date Free Form |
19 Jul 78 |
Category Codes |
7D; 99F |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323758420 |
Origin |
NTIS |
Type |
CAT |